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KMID : 1188320180120040420
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Gut and Liver
2018 Volume.12 No. 4 p.420 ~ p.425
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An Elevated Platelet Count Increases the Risk of Relapse in Ulcerative Colitis Patients with Mucosal Healing
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Nakarai Asuka
Kato Jun
Hiraoka Sakiko
Takashima Shiho
Inokuchi Toshihiro
Takahara Masahiro
Sugihara Yuusaku
Harada Keita
Okada Hiroyuki
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Abstract
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Background/Aims: Although mucosal healing (MH) has been considered a treatment goal for patients with ulcerative colitis (UC), the risk factors predictive of relapse in patients who achieve MH are unknown. Because the platelet count has been shown to be a marker of inflammation in inflammatory bowel diseases, this study aimed to assess whether the platelet count could predict relapse in UC patients with MH.
Methods: A prospective observational study was performed. UC patients with MH were consecutively enrolled in the study and monitored for at least 2 years or until relapse. The correlation between the incidence of relapse and the platelet count at the time of study enrollment was examined.
Results: In total, 43 patients were enrolled, and 14 patients (33%) relapsed. The median platelet count at the time of enrollment in the patients who relapsed significantly differed from that in the patients who did not relapse (27.2×104/μL vs 23.8×104/μL, respectively; p=0.016). A platelet count ＞25.0×104/μL was a significant risk factor for relapse based on a multivariate analysis (hazard ratio, 4.85; 95% confidence interval, 1.07 to 25.28), and according to the Kaplan-Meier analysis, this cutoff could identify patients susceptible to relapse (p=0.041, log-rank test).
Conclusions: The platelet count could be used as a predictor of relapse in UC patients with MH.
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KEYWORD
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Colitis, ulcerative, Mucosal healing, Platelet count, Recurrence
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